In vitro mimicry of essential fatty acid deficiency in human endothelial cells by TNFα impact of ω-3 versus ω-6 fatty acids

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In vitro mimicry of essential fatty acid deficiency in human endothelial cells by TNF impact of -3 versus -6 fatty acids

Severe endothelial abnormalities are a prominent feature in sepsis with cytokines such as tumor necrosis factor (TNF) being implicated in the pathogenesis. As mimic to inflammation, human umbilical vascular endothelial cells (HUVEC) were incubated with TNF for 22 h, in the absence or presence of the -6 fatty acid (FA), arachidonic acid (AA), or the alternative -3 FA eicosapentaenoic acid (EPA) ...

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high ω-3:ω-6 fatty acids ratio increases fatty acid binding protein 4 and extracellular secretory phospholipase a2iia in human ectopic endometrial cells

background: endometriosis, a common chronic inflammatory disorder, is defined by the atypical growth of endometrium- like tissue outside of the uterus. secretory phospholipase a2 group iia (spla2-iia) and fatty acid binding protein4 (fabp4) play several important roles in the inflammatory diseases. objective: due to reported potential anti-inflammatory effects of ω-3 and ω-6 fatty acids, the pu...

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Short communication:Influence of vacuum packaging and frozen storage time on fatty acids, amino acids and ω -3/ ω-6 ratio of rainbow trout (Oncorhynchus mykiss)

In this study rainbow trout (Oncorhynchus mykiss) fillets were vacuum packed, frozen and stored at -18°C and  the effect of this packaging method on proximate composition, fatty acids and amino acid profile and their changes compared to control conditions during 9 months of storage were studied. The results showed that 18 fatty acids were identified. The unsaturated fatty acid (UFA) were 56.77 ...

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ژورنال

عنوان ژورنال: Journal of Lipid Research

سال: 2002

ISSN: 0022-2275

DOI: 10.1016/s0022-2275(20)30469-7